Date of Award

9-1993

Document Type

Thesis

Degree Name

Master of Science

Department

Department of Mathematics and Statistics

Abstract

The goal of this study was to develop a physiologically based pharmacokinetic (PBPK) model that predicts mammalian blood concentrations of dibromomethane following exposure by dermal absorption more accurately than a previously developed Homogeneous Dermal Model. The Homogeneous Dermal Model contains a dermal compartment with no dermal sub-compartments. The 1:1 Dermal Model developed in this research contains a dermal compartment with a stratum corneum and a composite dermal sub-compartment of equal volume. This model yields predictions which are 21.4 percent more accurate than the original homogeneous model. In order to represent skin anatomy more accurately, the 1:10 Dermal Model variation was developed. The 1:10 Dermal model contains a dermal compartment with a composite dermal sub-compartment ten times the volume of the stratum corneum sub-compartment. The 1:10 Dermal Model yields predictions which are 17.7 percent more accurate than the original model. Finally, the 1:3:7 Dermal Model was developed which contains a viable epidermis sub-compartment three times the volume of the stratum corneum sub-compartment and a composite dermal sub-compartment which is seven times the volume of the stratum corneum sub-compartment. This model yields predictions 27.7 percent more accurate than the original model. Physiologically Based Pharmacokinetic model, Pharmacokinetic model, Mathematical model, Dermal Absorption.

AFIT Designator

AFIT-ENC-GEE-93S-2

DTIC Accession Number

ADA271106

Comments

The author's Vita page is omitted.

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