RNA molecules play many crucial roles in living systems. The spatial complexity that exists in RNA structures determines their cellular functions. Therefore, understanding RNA folding conformations, in particular, RNA secondary structures, is critical for elucidating biological functions. Existing literature has focused on RNA design as either an RNA structure prediction problem or an RNA inverse folding problem where free energy has played a key role.
Su, C., Weir, J. D., Zhang, F., Yan, H., & Wu, T. (2019). ENTRNA: A framework to predict RNA foldability. BMC Bioinformatics, 20(1), #373. https://doi.org/10.1186/s12859-019-2948-5