Document Type

Article

Publication Date

5-26-2011

Abstract

Altered tryptophan metabolism and indoleamine 2,3-dioxygenase activity are linked to cancer development and progression. In addition, these biological factors have been associated with the development and severity of neuropsychiatric syndromes, including major depressive disorder. However, this biological mechanism associated with both poor disease outcomes and adverse neuropsychiatric symptoms has received little attention in women with breast cancer. Therefore, a pilot study was undertaken to compare levels of tryptophan and other proteins involved in tryptophan degradation in women with breast cancer to women without cancer, and secondarily, to examine levels in women with breast caner over the course of chemotherapy.

Comments

This article is distributed under the terms of the Creative Commons Attribution 2.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 2.0

Sourced from the published version of record cited below.

DOI

10.1186/1756-0500-4-156

Source Publication

BMC Research Notes

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